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dc.contributor.authorSalces Ortiz, Judites_ES
dc.contributor.authorGonzález, Carmenes_ES
dc.contributor.authorMoreno Sánchez, Nataliaes_ES
dc.contributor.authorCalvo Lacosta, Jorge Hugoes_ES
dc.contributor.authorPérez-Guzmán Palomares, María Doloreses_ES
dc.contributor.authorSerrano Noreña, Magdalenaes_ES
dc.date.accessioned2013-07-11T11:21:02Z
dc.date.available2013-07-11T11:21:02Z
dc.date.issued2013es_ES
dc.identifier.citationPlos One, 8 (6), p. e66641en
dc.identifier.issn1932-6203*
dc.identifier.urihttp://hdl.handle.net/10532/2304
dc.description.abstractThe aim of this work was to investigate the association between polymorphisms located at the HSP90AA1 ovine gene promoter and gene expression rate under different environmental conditions, using a mixed model approach. Blood samples from 120 unrelated rams of the Manchega sheep breed were collected at three time points differing in environmental conditions. Rams were selected on the basis of their genotype for the transversion G/C located 660 base pairs upstream the gene transcription initiation site. Animals were also genotyped for another set of 6 SNPs located at the gene promoter. Two SNPs, G/C−660 and A/G−444, were associated with gene overexpression resulting from heat stress. The composed genotype CC−660-AG−444 was the genotype having the highest expression rates with fold changes ranging from 2.2 to 3.0. The genotype AG−522 showed the highest expression levels under control conditions with a fold change of 1.4. Under these conditions, the composed genotype CC−601-TT−524-AG−522-TT−468 is expected to be correlated with higher basal expression of the gene according to genotype frequencies and linkage disequilibrium values. Some putative transcription factors were predicted for binding sites where the SNPs considered are located. Since the expression rate of the gene under alternative environmental conditions seems to depend on the composed genotype of several SNPs located at its promoter, a cooperative regulation of the transcription of the HSP90AA1 gene could be hypothesized. Nevertheless epigenetic regulation mechanisms cannot be discarded.en
dc.language.isoeses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/es/*
dc.subject.otherproducción y sanidad animales_ES
dc.titleOvine HSP90AA1 Expression Rate Is Affected by Several SNPs at the Promoter under Both Basal and Heat Stress Conditionsen
dc.typeJournal Contribution*
dc.typearticle-
dc.bibliographicCitation.volume8 (6)es_ES
dc.bibliographicCitation.stpagee66641es_ES
dc.subject.agrovocOvinoses
dc.subject.agrovocGenotiposes
dc.subject.agrovocFactores climáticoses
dc.description.statusPublishedes_ES
dc.type.refereedNon-Refereedes_ES
dc.type.specifiedArticlees_ES
dc.bibliographicCitation.titlePlos Oneen
dc.relation.doi10.1371/journal.pone.0066641es_ES
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