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dc.contributor.authorMuñoz Álvaro, Pilar Maríaes_ES
dc.contributor.authorMick, Virginiees_ES
dc.contributor.authorSacchini, Lorenaes_ES
dc.contributor.authorJanowicz, Annaes_ES
dc.contributor.authorMiguel López, María Jesús dees_ES
dc.contributor.authorCherfa, Moulay-Alies_ES
dc.contributor.authorRodríguez Nevado, Celiaes_ES
dc.contributor.authorGirault, Guillaumees_ES
dc.contributor.authorAndrés Barranco, Saraes_ES
dc.contributor.authorJay, Marynees_ES
dc.contributor.authorGiannatale, Elisabetta dies_ES
dc.contributor.authorZilli, Katiusciaes_ES
dc.contributor.authorAncora, Massimoes_ES
dc.contributor.authorDondo, Alessandroes_ES
dc.contributor.authorZoppi, Simonaes_ES
dc.contributor.authorArnal, María Cruzes_ES
dc.contributor.authorTittarelli, Manuelaes_ES
dc.contributor.authorMassis, Fabrizio dees_ES
dc.contributor.authorGarin Bastuji, B.es_ES
dc.contributor.authorBlasco Martínez, José Maríaes_ES
dc.contributor.authorGarofolo, Giulianoes_ES
dc.coverage.spatialProducción y sanidad animales_ES
dc.date.accessioned2019-05-03T11:49:01Z-
dc.date.available2019-05-03T11:49:01Z-
dc.date.issued2019es_ES
dc.identifier.citationVeterinary Microbiology, vol. 233, (2019)-
dc.identifier.urihttp://hdl.handle.net/10532/4653-
dc.description.abstractSwine brucellosis due to Brucella suis biovar 2 (bv2) is enzootic in wild boar and hare in continental Europe and may cause major economic losses to the pig industry, mainly in free-ranged pig farms. The high nucleotide identity found among the B. suis biovar 2 isolates has long hindered the full understanding of the epidemiology and the phylogeography of the disease. Here, we used multilocus variable-number tandem-repeat (VNTR) analysis (MLVA) and whole-genome analysis to identify single-nucleotide polymorphisms (SNPs) in order to gain insights from the largest B. suis bv2 dataset analyzed so far composed of domestic pigs and wildlife isolates collected throughout Europe since the 1970s. We found four major clades with a specific phylogeographic pattern. The Iberian clade contains isolates exclusively from the Iberian Peninsula. The Central European clade includes most isolates from France, Northern Italy, Switzerland and an important proportion of those of Northern Spain. The Eastern European clade clustered isolates from Croatia and Hungary mainly but also from areas of France, Germany, Italy and Poland. Finally, a separated Sardinian clade grouped three isolates from this island. At fine scale, MLVA demonstrated an endemic status of the infection in Europe and it allowed tracking a large outbreak formed by different farms from Spain linked to the same infection source. The whole genome SNP analysis showed that the strains form genetically distinct clades, shared between wild boar and pigs, in agreement with the MLVA clades. Interestingly, all hare isolates clustered together within two groups composed exclusively of wildlife isolates. Our results support the hypothesis that maintenance and spread of B. suis bv2 in Europe is a dynamic process linked to the natural expansion of wild boar as the main wild reservoir of the infection, while spread over long distances is found largely dependent on anthropogenic activities.en
dc.language.isoenes_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titlePhylogeography and epidemiology of Brucella suis biovar 2 in wildlife and domestic swineen
dc.typeJournal Contribution*
dc.bibliographicCitation.volume233es_ES
dc.subject.agrovocBrucelosises
dc.subject.agrovocBrucella suises
dc.subject.agrovocAnimal salvajees
dc.subject.agrovocCerdoes
dc.subject.agrovocEpidemiologíaes
dc.description.statusUnpublishedes_ES
dc.type.refereedRefereedes_ES
dc.type.specifiedArticlees_ES
dc.bibliographicCitation.titleVeterinary Microbiologyen
dc.relation.doi10.1016/j.vetmic.2019.04.025es_ES
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