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Title: Rev1 wbdR tagged vaccines against Brucella ovis
Authors: Aragón Aranda, Beatriz
Miguel López, María Jesús de
Martínez Gómez, Estrella
Zúñiga Ripa, Amaia
Salvador Bescós, Miriam
Moriyón Uria, Ignacio
Iriarte, Maite
Muñoz Alvaro, Pilar María
Conde Álvarez, Raquel
Issue Date: 2019
Citation: Veterinary Research, vol. 50, (2019)
Abstract: Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.
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