Please use this identifier to cite or link to this item: http://hdl.handle.net/10532/5200
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dc.contributor.authorLakhssassi, Kenzaes_ES
dc.contributor.authorSerrano, Malenaes_ES
dc.contributor.authorLahoz Crespo, Belénes_ES
dc.contributor.authorSarto Aured, María Pilares_ES
dc.contributor.authorIguácel Quintana, Laura P.es_ES
dc.contributor.authorFolch Pera, Josées_ES
dc.contributor.authorAlabart Alvarez, José Luises_ES
dc.contributor.authorCalvo Lacosta, Jorge Hugoes_ES
dc.coverage.spatialProducción y sanidad animales_ES
dc.date.accessioned2021-01-15T11:10:21Z-
dc.date.available2021-01-15T11:10:21Z-
dc.date.issued2020es_ES
dc.identifier.citationAnimals, vol. 10, num. 12, (2020)-
dc.identifier.urihttp://hdl.handle.net/10532/5200-
dc.description.abstractThe aim of this study was to characterize and identify causative polymorphisms in the leptin receptor (LEPR) gene responsible for the seasonal variation of reproductive traits in sheep. Three reproductive seasonality traits were studied: the total days of anoestrous (TDA), the progesterone cycling months (P4CM) and the oestrous cycling months (OCM). In total, 18 SNPs were detected in 33 ewes with extreme values for TDA and OCM. Six SNPs were non-synonymous substitutions and two of them were predicted in silico as deleterious: rs596133197 and rs403578195. These polymorphisms were then validated in 239 ewes. The SNP rs403578195, located in exon 8 and leading to a change of alanine to glycine (Ala284Gly) in the extracellular domain of the protein, was associated with the OCM trait, being the G allele associated with a decrease of 12 percent of the OCM trait. Haplotype analyses also suggested the involvement of other non-synonymous SNP located in exon 20 (rs405459906). This SNP also produces an amino acid change (Lys1069Glu) in the intracellular domain of the protein and segregates independently of rs403578195. These results confirm for the first time the role of the LEPR gene in sheep reproductive seasonality.en
dc.language.isoenes_ES
dc.relation.urihttps://www.mdpi.com/2076-2615/10/12/2448es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleThe LEPR Gene Is Associated with Reproductive Seasonality Traits in Rasa Aragonesa Sheepen
dc.typeJournal Contribution*
dc.bibliographicCitation.volume10(12)es_ES
dc.subject.agrovocOvinoses
dc.subject.agrovocReproducciónes
dc.subject.agrovocGeneses
dc.description.otherRaza Rasa aragonesaen
dc.description.statusPublishedes_ES
dc.type.refereedRefereedes_ES
dc.type.specifiedArticlees_ES
dc.bibliographicCitation.titleAnimalsen
dc.relation.doi10.3390/ani10122448es_ES
Appears in Collections:[DOCIART] Artículos científicos, técnicos y divulgativos

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