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dc.contributor.authorLahoz Crespo, Belénes_ES
dc.contributor.authorAlabart Alvarez, José Luises_ES
dc.contributor.authorMonniaux, Daniellees_ES
dc.contributor.authorMermillod, Pascales_ES
dc.contributor.authorFolch Pera, Josées_ES
dc.date.accessioned2012-08-27T10:48:17Z-
dc.date.available2012-08-27T10:48:17Z-
dc.date.issued2012es_ES
dc.identifier.citationFolch Belén Lahoz, José L Alabart, Danielle Monniaux, Pascal Mermillod and José. “Anti-Mullerian hormone plasma concentration in prepubertal ewe lambs as a predictor of their fertility at a young age”. BMC Veterinary Research 2012, 8:118 doi:10.1186/1746-6148-8-118, 19 p.-
dc.identifier.urihttp://hdl.handle.net/10532/1954-
dc.descriptionPublished: 23 July 2012- Provisionales_ES
dc.description.abstractBackground In mammals, the ovarian follicular reserve is highly variable between individuals and impacts strongly on ovarian function and fertility. Nowadays, the best endocrine marker of this reserve in human, mouse and cattle is the anti-Mullerian hormone (AMH). The objectives of this work were to determine whether AMH could be detected in the plasma of prepubertal ewe lambs and to assess its relationship with their fertility at a young age. Results Plasma was taken from 76 Rasa Aragonesa ewe lambs at 3.6 months of age for AMH determination. Simultaneously, 600 IU equine chorionic gonadotropin (eCG) was administered and the number of ovulations recorded 6 days later. AMH was detected in 93 % of the lambs, and the concentrations were about 3-4-fold higher in ovulating than in non-ovulating lambs (P < 0.004). Ewes aged around 10 months were mated, giving an overall fertility of 29 %, and those failing to conceive were mated again 4 months later. Fertility at first mating was significantly correlated with plasma AMH concentration at 3.6 months (Spearman's rho = 0.34; P < 0.01). To use plasma AMH concentration as a screening test, a value of 97 pg/mL was determined as the optimum cutoff value to predict fertility at first mating (sensitivity = 68.2 %; specificity = 72.2 %). Fertility at first mating was 34.8 percentage points higher in ewe lambs with an AMH [greater than or equal to] 97 pg/mL than in those with lower AMH concentrations (50 % vs. 15 %; P < 0.001). Conclusions Plasma AMH concentration might be a reliable marker of the ovarian status of prepubertal ewe lambs, reflecting their ability to respond to eCG stimulation. A single AMH measurement performed on ewe lambs early in age could be useful to select for replacement ewes with a higher predicted fertility at first mating.en
dc.language.isoenes_ES
dc.subject.otherOvinos-
dc.subject.otherHormonas-
dc.subject.otherFertilidad-
dc.subject.otherProducción y sanidad animales_ES
dc.titleAnti-Mullerian hormone plasma concentration in prepubertal ewe lambs as a predictor of their fertility at a young ageen
dc.typeArticlees_ES
dc.relation.publisherversionhttp://www.biomedcentral.com/1746-6148/8/118/abstract-
dc.description.statusUnpublishedes_ES
dc.type.refereedNon-Refereedes_ES
dc.type.specifiedArticlees_ES
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