Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10532/2802
Registro completo de metadatos
Campo DC Valor Idioma
dc.contributor.authorSalces Ortiz, Judites_ES
dc.contributor.authorGonzález Verdejo, Mª Carmenes_ES
dc.contributor.authorMartínez, Martaes_ES
dc.contributor.authorMayoral, Tomáses_ES
dc.contributor.authorCalvo Lacosta, Jorge Hugoes_ES
dc.contributor.authorSerrano Noreña, Magdalenaes_ES
dc.date.accessioned2015-02-19T12:32:37Z
dc.date.available2015-02-19T12:32:37Z
dc.date.issued2015es_ES
dc.identifier.citationBmc Evolutionary Biology, 15 (7)en
dc.identifier.issn1471-2148*
dc.identifier.urihttp://hdl.handle.net/10532/2802
dc.description.abstractBackgroundClimatic factors play an important role in determining species distributions and phenotypic variation of populations over geographic space. Since domestic sheep is managed under low intensive systems animals could have retained some genome adaptive footprints. The gene encoding the Hsp90? has been extensively studied in sheep and some polymorphisms located at its promoter have been associates with differences in the transcription rate of the gene depending on climatic conditions. In this work the relationships among the distribution and frequencies of 11 polymorphisms of the ovine HSP90AA1 gene promoter in 31 sheep breeds and the climatic and geographic variables prevailing in their regions of origin have been studied. Also the promoter sequence has been characterized in 9 species of the Caprinae subfamily. ResultsCorrelations among several climatic variables and allele frequencies of the polymorphisms of the HSP90AA1 gene promoter linked with differences in the transcription activity of the gene under heat stress conditions have been assessed. A group of breeds reared in semi dry climates have high frequencies of the insertion allele of the g.667-668insC associated with the heat stress response. Other group of breeds native to semi arid conditions showed very low frequencies of this same allele. However, in some cases, this previous correlation has not been achieved, revealing the high levels of gene flow among populations occurred following domestication. The Bayesian Test of Beaumont and Balding identified two outlier loci, the g.522A?>?G and g.703_704del(2)A candidates to balancing and directional selection, respectively. Polymorphisms detected in O. aries are also present in several species of the Caprinae subfamily being C. hircus, O. musimon and O. moschatus those sharing the highest number of them with O. aries.ConclusionsDespite domestication, sheep breeds showed some genetic footprints related to climatic variables. Adaptation of breeds to heat climates can suppose a selective advantage to cope with global warming caused by climatic change. Polymorphisms of the HSP90AA1 gene detected in the Ovis aries species are also present in wild species from the Caprinae subfamily, indicating a great antiquity of these mutations and its importance in the adaptation of species to past climatic conditions existing in its native environments.en
dc.language.isoenes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/es/*
dc.subject.otherproducción y sanidad animales_ES
dc.titleLooking for adaptive footprints in the HSP90AA1 ovine geneen
dc.typeJournal Contribution*
dc.typearticle-
dc.bibliographicCitation.volume15 (7)es_ES
dc.subject.agrovocRazas (animales)es
dc.subject.agrovocOvinoses
dc.subject.agrovocFactores climáticoses
dc.subject.agrovocHerencia genéticaes
dc.description.statusPublishedes_ES
dc.type.refereedNon-Refereedes_ES
dc.type.specifiedArticlees_ES
dc.bibliographicCitation.titleBmc Evolutionary Biologyen
dc.relation.doidoi:10.1186/s12862-015-0280-xes_ES
Aparece en las colecciones: [DOCIART] Artículos científicos, técnicos y divulgativos

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
2015_026.pdf662,11 kBAdobe PDFVista previa
Visualizar/Abrir


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons

La información de este repositorio es indexada en: