Maternal Hydroxytyrosol Supplementation Enhances Antioxidant Capacity and Immunometabolic Adaptations in Nutrient-Restricted Beef Cows and Their Offspring
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Date
2025-09-08
Authors
Escalera Moreno, NievesAlvarez Rodríguez, Javier
López de Armentia Osés, Leire
Macia, Alba
Martín Alonso, María José
Molina Ureste, Ester
Villalba Mata, Daniel
Sanz Pascua, Albina
Serrano Pérez, Beatriz
Journal Title
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Volume Title
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MDPI
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texto , revista , artículo , artículo originalAbstract
The impact of maternal dietary restriction and hydroxytyrosol (HT) supplementation during the last third of gestation on plasma malondialdehyde (MDA) concentration, total antioxidant capacity (ABTS assay), and peripheral blood gene expression related to antioxidant defence, immune response, and energy metabolism was evaluated in beef cows and calves. Two feeding treatments in late gestation (T100% vs. T60% of nutrient requirements) and two HT levels (Control vs. HT at 180 mg/kg of diet) were evaluated during gestation (n = 46 cows) and lactation (n = 37 cows and calves). In pregnant cows, undernutrition led to inhibition of glucose oxidation (PDK4), decreased lipid synthesis (HMGCS1 and SCD) and TLR signalling; T60% cows showed higher plasma MDA (p < 0.05) with no positive effect of HT on antioxidant capacity. Contrarily, during lactation, earlier HT supplementation upregulated antioxidant capacity and modulated antioxidant gene expression (p < 0.05). In calves, there was an increase in SOD1, CAT, and GPX1, especially in the T60%-HT group (p < 0.05). Interestingly, HT supplementation increased glucose transport (SLC2A1/GLUT1) during pregnancy and lactation (p < 0.05). However, it caused different effects on immunometabolic regulation in both dams and calves, depending on maternal diet. Overall, maternal HT supplementation under restricted nutritional conditions promoted postpartum antioxidant capacity and modulated immune and metabolic gene expression in cows and calves.
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Bibliographic citation
Escalera-Moreno, N., Álvarez-Rodríguez, J., López de Armentia, L., Macià, A., Martín-Alonso, M. J., Molina, E., Villalba, D., Sanz, A., & Serrano-Pérez, B. (2025). Maternal Hydroxytyrosol Supplementation Enhances Antioxidant Capacity and Immunometabolic Adaptations in Nutrient-Restricted Beef Cows and Their Offspring. Antioxidants, 14(9), 1097. https://doi.org/10.3390/antiox14091097
AGROVOC subjects
Carne de terneraNutrición animal
Estrés oxidativo
Antioxidante
Expresión génica
Sponsorship
Este trabajo formó parte del proyecto PID2020-113617RR-C22, financiado por MICIU/AEI/10.13039/501100011033 (FETALNUT, Ministerio de Ciencia, Innovación y Universidades, Gobierno de España), el Gobierno de Aragón (subvención para el grupo de investigación INPASS A25_23R) y el Gobierno de Cataluña (2021 SGR 01361).