Maternal Hydroxytyrosol Supplementation Enhances Antioxidant Capacity and Immunometabolic Adaptations in Nutrient-Restricted Beef Cows and Their Offspring

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dc.contributor.authorEscalera Moreno, Nieves
dc.contributor.authorAlvarez Rodríguez, Javier
dc.contributor.authorLópez de Armentia Osés, Leire
dc.contributor.authorMacia, Alba
dc.contributor.authorMartín Alonso, María José
dc.contributor.authorMolina Ureste, Ester
dc.contributor.authorVillalba Mata, Daniel
dc.contributor.authorSanz Pascua, Albina
dc.contributor.authorSerrano Pérez, Beatriz
dc.contributor.funderAgencia Estatal de Investigación
dc.contributor.funderGobierno de Aragón
dc.contributor.funderGeneralitat de Catalunya
dc.contributor.orcidLópez de Armentia Osés, Leire [0009-0006-8959-3667]
dc.contributor.orcidSanz Pascua, Albina [0000-0002-8122-0069]
dc.contributor.orcidSerrano Pérez, Beatriz [0000-0002-8772-6335]
dc.date.accessioned2025-09-12T11:54:54Z
dc.date.available2025-09-12T11:54:54Z
dc.date.issued2025-09-08
dc.date.updated2025-09-12T06:02:00Z
dc.description.abstractThe impact of maternal dietary restriction and hydroxytyrosol (HT) supplementation during the last third of gestation on plasma malondialdehyde (MDA) concentration, total antioxidant capacity (ABTS assay), and peripheral blood gene expression related to antioxidant defence, immune response, and energy metabolism was evaluated in beef cows and calves. Two feeding treatments in late gestation (T100% vs. T60% of nutrient requirements) and two HT levels (Control vs. HT at 180 mg/kg of diet) were evaluated during gestation (n = 46 cows) and lactation (n = 37 cows and calves). In pregnant cows, undernutrition led to inhibition of glucose oxidation (PDK4), decreased lipid synthesis (HMGCS1 and SCD) and TLR signalling; T60% cows showed higher plasma MDA (p < 0.05) with no positive effect of HT on antioxidant capacity. Contrarily, during lactation, earlier HT supplementation upregulated antioxidant capacity and modulated antioxidant gene expression (p < 0.05). In calves, there was an increase in SOD1, CAT, and GPX1, especially in the T60%-HT group (p < 0.05). Interestingly, HT supplementation increased glucose transport (SLC2A1/GLUT1) during pregnancy and lactation (p < 0.05). However, it caused different effects on immunometabolic regulation in both dams and calves, depending on maternal diet. Overall, maternal HT supplementation under restricted nutritional conditions promoted postpartum antioxidant capacity and modulated immune and metabolic gene expression in cows and calves.
dc.description.sponsorshipEste trabajo formó parte del proyecto PID2020-113617RR-C22, financiado por MICIU/AEI/10.13039/501100011033 (FETALNUT, Ministerio de Ciencia, Innovación y Universidades, Gobierno de España), el Gobierno de Aragón (subvención para el grupo de investigación INPASS A25_23R) y el Gobierno de Cataluña (2021 SGR 01361).
dc.identifier.citationEscalera-Moreno, N., Álvarez-Rodríguez, J., López de Armentia, L., Macià, A., Martín-Alonso, M. J., Molina, E., Villalba, D., Sanz, A., & Serrano-Pérez, B. (2025). Maternal Hydroxytyrosol Supplementation Enhances Antioxidant Capacity and Immunometabolic Adaptations in Nutrient-Restricted Beef Cows and Their Offspring. Antioxidants, 14(9), 1097. https://doi.org/10.3390/antiox14091097
dc.identifier.doi10.3390/antiox14091097
dc.identifier.issn2076-3921
dc.identifier.urihttps://hdl.handle.net/10532/7818
dc.language.isoen
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2020-113617RR-C22/ES/EFECTOS DE LA SUBNUTRICION FETAL Y DEL USO DE HIDROXITIROSOL EN EL ULTIMO TERCIO DE GESTACION SOBRE EL ESTADO OXIDATIVO E INMUNE Y EL METABOLISMO LIPIDICO EN VACUNO DE CARNE/FETALNUT
dc.relationinfo:eu-repo/grantAgreement/Gobierno de Aragón/III Plan Autonómico de Investigación, Desarrollo e Innovación 2021-2027/A25_23R/ES/Investigación en producción agroganadera sostenible y saludable/INPASS
dc.relation.citaSi
dc.relation.publisherversionhttps://doi.org/10.3390/antiox14091097
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spainen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.agrovocCarne de ternera
dc.subject.agrovocNutrición animal
dc.subject.agrovocEstrés oxidativo
dc.subject.agrovocAntioxidante
dc.subject.agrovocExpresión génica
dc.subject.sdgHambre cero
dc.subject.sdgProducción y consumo responsables
dc.titleMaternal Hydroxytyrosol Supplementation Enhances Antioxidant Capacity and Immunometabolic Adaptations in Nutrient-Restricted Beef Cows and Their Offspring
dc.typetexto
dc.typerevista
dc.typeartículo
dc.typeartículo original

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