Anti-Trichomonas gallinae activity of essential oils and main compounds from Lamiaceae and Asteraceae plants

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dc.bibliographicCitation.titleFrontiers in Veterinary Scienceen
dc.bibliographicCitation.volume9es_ES
dc.contributor.authorBailén, Maríaes_ES
dc.contributor.authorDíaz Castellanos, Irenees_ES
dc.contributor.authorAzami Conesa, Irises_ES
dc.contributor.authorAlonso Fernández, Saraes_ES
dc.contributor.authorMartínez Díaz, Rafael A.es_ES
dc.contributor.authorNavarro Rocha, Julianaes_ES
dc.contributor.authorGómez Muñoz, María Teresaes_ES
dc.contributor.authorGonzález Coloma, Azucenaes_ES
dc.coverage.spatialCiencia vegetales_ES
dc.date.accessioned2022-10-13T07:58:01Z
dc.date.available2022-10-13T07:58:01Z
dc.date.issued2022es_ES
dc.description.abstractTrichomonas gallinae is a flagellated protozoan that parasitizes the upper digestive tract of various bird species and causes avian trichomonosis. The emergence of resistant strains to the standard treatment, based on nitroimidazoles, increases the need to find alternative therapies. In this study, 36 essential oils (EOs) from Lamiaceae and Asteraceae plant families were tested against T. gallinae trophozoites using the 3-(4,5-dimethylthiazol-2-yl-)-2,5-dipheniltetrazolium bromide (MTT) reduction assay. Among them, EOs from distinct species of Lamiaceae, including the genera Lavandula, Salvia, Thymus, Origanum, and Satureja were the ones reporting better anti-trichomonal activity, and were selected for further analysis, including chemical composition and in vitro assays. The chemical composition of the selected EOs was determined by gas chromatography followed by mass spectrometry and 19 pure compounds were tested against the protozoa, according to their higher abundance in the active EOs. Pure compounds which displayed the highest activity against T. gallinae trophozoites, ordered by highest to lowest activity, were α and β-thujones, camphene, β-pinene, linalyl acetate, thymol, 4-terpineol, γ-terpinene, α-pinene, p-cymene, D-fenchone and β-caryophyllene. A dose dependent effect was observed in most of the EOs and pure compounds tested. The toxicity test conducted in eukaryotic cell cultures with the anti-trichomonal active pure compounds showed that β-caryophyllene, camphene, α-pinene, and β-pinene were slightly toxic for Vero cells, and the selectivity index was calculated. Based on the anti-trichomonal activity and the absence of cytotoxicity results, natural products from Lamiaceae plants could be useful as alternative therapy against avian trichomonosis, mainly those containing linalyl acetate, thymol, 4-terpinenol, γ-terpinene, p-cymene and D-fenchone.en
dc.description.statusPublishedes_ES
dc.identifier.citationFrontiers in Veterinary Science, vol. 9, (2022)
dc.identifier.urihttp://hdl.handle.net/10532/6116
dc.language.isoenes_ES
dc.relation.doi10.3389/fvets.2022.981763es_ES
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fvets.2022.981763es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subject.agrovocAceites esencialeses
dc.subject.agrovocLamiaceaees
dc.subject.agrovocAsteraceaees
dc.subject.agrovocTrichomonases
dc.subject.agrovocAntimicrobianoses
dc.titleAnti-Trichomonas gallinae activity of essential oils and main compounds from Lamiaceae and Asteraceae plantsen
dc.typeJournal Contribution*
dc.type.refereedRefereedes_ES
dc.type.specifiedArticlees_ES

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