New insights into the pathogenesis and transmission of Brucella pinnipedialis: systemic infection in two bottlenose dolphins ( Tursiops truncatus)

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dc.bibliographicCitation.titleMicrobiology Spectrumen
dc.contributor.authorVargas Castro, Ignacioes_ES
dc.contributor.authorCRESPO PICAZO, JOSE LUISes_ES
dc.contributor.authorFayos, Manenaes_ES
dc.contributor.authorJiménez Martínez, María de los Ángeleses_ES
dc.contributor.authorTorre Fuentes, Lauraes_ES
dc.contributor.authorAlvarez, Julioes_ES
dc.contributor.authorMoura, André E.es_ES
dc.contributor.authorHernandez, Martaes_ES
dc.contributor.authorBuendía, Aranzazues_ES
dc.contributor.authorBarroso Arévalo, Sandraes_ES
dc.contributor.authorGarcía Seco, Teresaes_ES
dc.contributor.authorPérez Sancho, Martaes_ES
dc.contributor.authorMiguel López, María Jesús dees_ES
dc.contributor.authorAndrés Barranco, Saraes_ES
dc.contributor.authorMarco Cabedo, Vicentees_ES
dc.contributor.authorPeñin Villahoz, Gaizkaes_ES
dc.contributor.authorMuñoz Álvaro, Pilar Maríaes_ES
dc.contributor.authorDominguez, Lucases_ES
dc.contributor.authorGarcía Párraga, Danieles_ES
dc.contributor.authorSánchez Vizcaíno, José Manueles_ES
dc.coverage.spatialCantabria (España)es_ES
dc.date.accessioned2023-10-09T12:25:47Z
dc.date.available2023-10-09T12:25:47Z
dc.date.issued2023es_ES
dc.date.updated2023-10-09T12:10:13Z
dc.description.abstractThe emergence of Brucella infections in marine mammals is a growing concern. The present study reports two cases of systemic Brucella pinnipedialis infection detected in bottlenose dolphins (Tursiops truncatus) pair stranded together in the Cantabrian coast of Spain. Both animals showed systemic lesions associated with the Brucella infection, more severe in the younger dolphin, considered the likely offspring of the other individual. Real-time PCR, bacterial culture, and whole-genome sequencing were used to detect and characterize the Brucella strains involved in both dolphins. The phylogenetic analysis performed on the Brucella genomes retrieved revealed that the species involved was B. pinnipedialis (ST25). Both animals resulted seropositive in a commercial multispecies blocking ELISA but tested negative in the standard Rose Bengal test. To the best of our knowledge, this is the first report of a systemic infection resulting in various lesions associated with Brucella pinnipedialis (ST25) in two bottlenose dolphins. It is also the initial isolation of Brucella in the milk of a non-pregnant or non-aborting female cetacean likely stranded with its offspring. These findings provide new insights into the epidemiology and clinical impact of B. pinnipedialis infection in cetaceans and underscore the importance of continued diagnostic surveillance to gain better understanding of brucellosis effects and transmission in marine mammal populations.en
dc.description.othermilken
dc.description.otherBrucella pinnipedialisen
dc.description.otherbottlenose dolphinen
dc.description.othermarine mammalsen
dc.description.othersystemic infectionen
dc.description.otherhealth surveillanceen
dc.description.othertransmissionen
dc.description.otherwhole-genome sequencingen
dc.description.sponsorshipEste trabajo ha contado con el apoyo de un convenio de colaboración entre la Fundación Oceanogràfic (Valencia), la Consejería de Medio Rural, Ganadería, Pesca, Alimentación y Medio Ambiente del Gobierno de Cantabria y el Centro de Vigilancia Sanitaria Veterinaria (VISAVET) de la Universidad Complutense de Madrid. Este convenio permite la recogida de muestras de cadáveres de cetáceos varados y aporta fondos para la realización de estudios post-mortem. Ignacio Vargas-Castro es beneficiario de una beca FPU del Ministerio de Ciencia, Innovación y Universidades. El trabajo del CITA fue apoyado por el Gobierno de Aragón (Grupo de Investigación A21_23R). André E. Moura recibió el apoyo del Centro Nacional de Ciencia de Polonia (beca de investigación Sonata 2018/31/D/NZ8/02835) y de la Agencia Nacional Polaca de Intercambio Académico (programa NAWA Ulam PPN/ ULM/2019/1/00162).es_ES
dc.description.statusPublishedes_ES
dc.identifier.citationMicrobiology Spectrum, 2023, e01997-23-NA
dc.identifier.issn21650497
dc.identifier.urihttp://hdl.handle.net/10532/6631
dc.language.isoenes_ES
dc.relation.doihttps://doi.org/10.1128/spectrum.01997-23es_ES
dc.relation.urihttps://doi.org/10.1128/spectrum.01997-23es_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Spaines_ES
dc.subject.agrovocLechees
dc.subject.agrovocBrucellaes
dc.subject.agrovocDelfínes
dc.subject.agrovocMamíferos marinoses
dc.subject.agrovocInfecciónes
dc.subject.agrovocVigilancia de enfermedadeses
dc.subject.agrovocSecuencia de ADNes
dc.titleNew insights into the pathogenesis and transmission of Brucella pinnipedialis: systemic infection in two bottlenose dolphins ( Tursiops truncatus)en
dc.typearticle*
dc.type.refereedRefereedes_ES
dc.type.specifiedArticlees_ES

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