Phenolic compounds and multifunctional properties of thinned apples: revalorizing fruit by-products for industrial applications

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dc.contributor.authorCano-Lou, Javier
dc.contributor.authorCasado-Hidalgo, Gema
dc.contributor.authorLes, Francisco
dc.contributor.authorPina Sobrino, Ana
dc.contributor.authorAcquaticci, Laura
dc.contributor.authorCaprioli, Giovanni
dc.contributor.authorLopez, Victor
dc.contributor.orcidPina Sobrino, Ana [0000-0002-4988-9467]
dc.date.accessioned2026-02-13T11:42:20Z
dc.date.available2026-02-13T11:42:20Z
dc.date.updated2026-02-09T13:23:55Z
dc.description.abstractThinned apples are a common by-product of apple orchards, produced in abundant quantities through thinning or natural drop, leading to the loss of substantial amounts of phenolic compounds with potential bioactive properties. Ten thinned apple samples, representing both commercial and autochthonous cultivars, were ultrasonicated using ethanol as green solvent, with the main goal of reusing their phenolic content for industrial and nutritional applications. For this reason, the phenolic content was characterized with high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). The antioxidant, antidiabetic, and cardiovascular activities were evaluated and correlated with the targeted phenolic compounds. Under non-cytotoxic conditions in Caco-2, HepG2 and HFF-1 cells, Amarilla de Octubre and Pomera de Pomes Agrias showed the strongest antioxidant-antiglycation activity as well as ACE inhibition, while Reineta and Verde Doncella excelled in HMGR and ACE inhibition. Pomera de Pomes Agrias, Vadiello-02, Reineta and Verde Doncella led digestive enzymes under Caco-2 safety.
dc.description.peerreviewedSi
dc.description.sponsorshipEste trabajo forma parte del proyecto APPLEDIV (Enfoque multidisciplinar para explotar la diversidad genética con el fin de aumentar el valor de la manzana autóctona: valorización de los subproductos y residuos locales de la manzana a través de compuestos bioactivos PID2022-141847OR-C33), financiado por la Agencia Estatal de Investigación en la convocatoria de 2022 de proyectos de generación de conocimiento orientados a los retos sociales. Traducción realizada con la versión gratuita del traductor DeepL.com
dc.identifier.citationCano-Lou, J., Casado-Hidalgo, G., Les, F., Pina, A., Acquaticci, L., Caprioli, G., & López, V. (2026). Phenolic compounds and multifunctional properties of thinned apples: Revalorizing fruit by-products for industrial applications. Food Chemistry: X, 103640. https://doi.org/10.1016/j.fochx.2026.103640
dc.identifier.doi10.1016/j.fochx.2026.103640
dc.identifier.issn2590-1575
dc.identifier.urihttps://doi.org/10.1016/j.fochx.2026.103640
dc.identifier.urihttps://hdl.handle.net/10532/8141
dc.language.isoen
dc.publisherElsevier B.V.
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-141847OR-C31/ES/ENFOQUE MULTIDISCIPLINAR PARA VALORIZAR LA DIVERSIDAD GENETICA DEL MANZANO AUTOCTONO: DESCUBRIENDO PROCESOS BIOQUIMICOS, AROMATICOS Y METABOLOMICOS ASOCIADOS A LA APTITUD/APPLEDIV
dc.relation.citaSi
dc.relation.publisherversionhttps://doi.org/10.1016/j.fochx.2026.103640
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.agrovocMalus domestica
dc.subject.agrovocSubproducto
dc.subject.agrovocCompuesto fenólico
dc.subject.agrovocExtracción
dc.subject.agrovocAntioxidante
dc.subject.sdgHambre cero
dc.titlePhenolic compounds and multifunctional properties of thinned apples: revalorizing fruit by-products for industrial applications
dc.typetexto
dc.typerevista
dc.typeartículo
dc.typeartículo original
dc.type.hasVersionversión publicada

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