Elucidating Sources and Roles of Granzymes A and B during Bacterial Infection and Sepsis

Simple item page
dc.bibliographicCitation.endpage429es_ES
dc.bibliographicCitation.stpage420es_ES
dc.bibliographicCitation.titleCell Reportsen
dc.bibliographicCitation.volume8es_ES
dc.contributor.authorArias Cabrero, Maykel Albertoes_ES
dc.contributor.authorJiménez de Bagüés Picazo, María Pilares_ES
dc.contributor.authorAguiló, Nachoes_ES
dc.contributor.authorMenao, Sebastiánes_ES
dc.contributor.authorHervás Stubbs, Sandraes_ES
dc.contributor.authorMartino, Alba dees_ES
dc.contributor.authorAlcaraz, Anaes_ES
dc.contributor.authorSimon, Markus, M.es_ES
dc.contributor.authorFroelich, Christopher J.es_ES
dc.contributor.authorPardo, Juliánes_ES
dc.date.accessioned2014-08-18T08:29:31Z
dc.date.available2014-08-18T08:29:31Z
dc.date.issued2014es_ES
dc.description.abstractDuring bacterial sepsis, proinflammatory cytokines contribute to multiorgan failure and death in a process regulated in part by cytolytic cell granzymes. When challenged with a sublethal dose of the identified mouse pathogen Brucella microti, wild-type (WT) and granzyme A (gzmA)−/− mice eliminate the organism from liver and spleen in 2 or 3 weeks, whereas the bacteria persist in mice lacking perforin or granzyme B as well as in mice depleted of Tc cells. In comparison, after a fatal challenge, only gzmA−/− mice exhibit increased survival, which correlated with reduced proinflammatory cytokines. Depletion of natural killer (NK) cells protects WT mice from sepsis without influencing bacterial clearance and the transfer of WT, but not gzmA−/− NK, cells into gzmA−/− recipients restores the susceptibility to sepsis. Therefore, infection-related pathology, but not bacterial clearance, appears to require gzmA, suggesting the protease may be a therapeutic target for the prevention of bacterial sepsis without affecting immune control of the pathogenen
dc.description.statusPublishedes_ES
dc.identifier.citationCell Reports, 8, p. 420-429en
dc.identifier.urihttp://hdl.handle.net/10532/2612
dc.language.isoenes_ES
dc.relation.doihttp://dx.doi.org/10.1016/j.celrep.2014.06.012es_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/es/*
dc.subject.agrovocInfecciónde
dc.subject.agrovocSerinade
dc.subject.agrovocBacteriosises
dc.subject.otherproducción y sanidad animales_ES
dc.titleElucidating Sources and Roles of Granzymes A and B during Bacterial Infection and Sepsisen
dc.typeJournal Contribution*
dc.typearticle
dc.type.refereedNon-Refereedes_ES
dc.type.specifiedArticlees_ES

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2014_187.pdf
Size:
1.84 MB
Format:
Adobe Portable Document Format
Download

Collections

Artículos científicos, técnicos y divulgativos