Genomic and phenotypic analysis of invasive Streptococcus suis isolated in Spain reveals genetic diversification and associated virulence traits

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dc.bibliographicCitation.stpage11es_ES
dc.bibliographicCitation.titleVeterinary Researchen
dc.bibliographicCitation.volume55es_ES
dc.contributor.authorUruén García, Cristina es_ES
dc.contributor.authorFernandez, Anaes_ES
dc.contributor.authorArnal, José Luíses_ES
dc.contributor.authordel Pozo, Mateoes_ES
dc.contributor.authorCasas Amoribieta, Mariaes_ES
dc.contributor.authorde Blas Giral, Ignacioes_ES
dc.contributor.authorJurado Romero, Paulaes_ES
dc.contributor.authorCalvo Lacosta, Jorge Hugoes_ES
dc.contributor.authorGottschalk, Marceloes_ES
dc.contributor.authorGonzález-Vázquez, Luis Danieles_ES
dc.contributor.authorArenas, Migueles_ES
dc.contributor.authorMarín Alcalá, Clara Maríaes_ES
dc.contributor.authorArenas Busto, Jesúses_ES
dc.coverage.spatialEspañaes_ES
dc.date.accessioned2024-01-31T09:04:41Z
dc.date.available2024-01-31T09:04:41Z
dc.date.issued2024es_ES
dc.date.updated2024-01-31T08:56:46Z
dc.description.abstractStreptococcus suis is a zoonotic pathogen that causes a major health problem in the pig production industry worldwide. Spain is one of the largest pig producers in the world. This work aimed to investigate the genetic and phenotypic features of invasive S. suis isolates recovered in Spain. A panel of 156 clinical isolates recovered from 13 Autonomous Communities, representing the major pig producers, were analysed. MLST and serotyping analysis revealed that most isolates (61.6%) were assigned to ST1 (26.3%), ST123 (18.6%), ST29 (9.6%), and ST3 (7.1%). Interestingly, 34 new STs were identified, indicating the emergence of novel genetic lineages. Serotypes 9 (27.6%) and 1 (21.8%) prevailed, followed by serotypes 7 (12.8%) and 2 (12.2%). Analysis of 13 virulence-associated genes showed significant associations between ST, serotype, virulence patterns, and clinical features, evidencing particular virulence traits associated with genetic clusters. The pangenome was generated, and the core genome was distributed in 7 Bayesian groups where each group included a variable set of over- and under-represented genes of different categories. The study provides comprehensive data and knowledge to improve the design of new vaccines, antimicrobial treatments, and bacterial typing approaches.en
dc.description.otherStreptococcus suisen
dc.description.otherepidemiologyen
dc.description.othervirulence factorsen
dc.description.othergenetic recombinationen
dc.description.sponsorshipEste trabajo ha recibido financiación del Ministerio de Ciencia e Innovación/Agencia Española de investigación MCIN/AEI/https://doi.org/10. 13039/501100011033 y, en su caso, por el FEDER A way of making Europe de la Unión Europea o por la Unión Europea NextGenerationEU/PRTR (Convenio de subvención PID2020-114617RB-100), del Gobierno de Aragón (Departamento de Proyectos de I+D+i en líneas prioritarias, Convenio de subvención LMP58_21), y por la Universidad de Zaragoza (Convenio de subvención UZ2020-BIO-01).es_ES
dc.description.statusPublishedes_ES
dc.identifier.citationUruén, C., Fernandez, A., Arnal, J. L., del Pozo, M., Amoribieta, M. C., de Blas, I., Jurado, P., Calvo, J. H., Gottschalk, M., González-Vázquez, L. D., Arenas, M., Marín, C. M., & Arenas, J. (2024). Genomic and phenotypic analysis of invasive Streptococcus suis isolated in Spain reveals genetic diversification and associated virulence traits. Veterinary Research, 55 (1), 11. https://doi.org/10.1186/s13567-024-01267-0
dc.identifier.issn09284249
dc.identifier.urihttp://hdl.handle.net/10532/6846
dc.language.isoenes_ES
dc.relation.doihttps://doi.org/10.1186/s13567-024-01267-0es_ES
dc.relation.urihttps://doi.org/10.1186/s13567-024-01267-0es_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Spaines_ES
dc.subject.agrovocStreptococcus suises
dc.subject.agrovocEpidemiologíaes
dc.subject.agrovocVirulenciaes
dc.subject.agrovocRecombinación genéticaes
dc.subject.agrovocepidemiology virulence factors genetic recombinationen
dc.titleGenomic and phenotypic analysis of invasive Streptococcus suis isolated in Spain reveals genetic diversification and associated virulence traitsen
dc.typearticle*
dc.type.refereedRefereedes_ES
dc.type.specifiedArticlees_ES

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