A SNP in the HSP90AA1 gene 5′ flanking region is associated with the adaptation to differential thermal conditions in the ovine species
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Date
2010
Authors
Marcos Carcavilla, AneMutikainen, Mari
González Verdejo, Mª Carmen
Calvo Lacosta, Jorge Hugo
Kantanen, Juha
Sanz Pascua, Albina
Marzanov, Nurbiy
Pérez-Guzmán Palomares, María Dolores
Serrano Noreña, Magdalena
Journal Title
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ArticleAbstract
Molecular chaperones have long been understood
to be preferentially transcribed in response to multiple
perturbations of the cellular homeostasis. In this study,
several polymorphisms in the gene encoding the inducible
form of the cytoplasmic Hsp90 (HSP90AA1) were
addressed in 24 sheep breeds reared in different climatic
regions of Europe, Africa, and Asia. Significant differences
in the genotype frequencies for a C/G single nucleotide
polymorphism (SNP) located at position −660 in the
HSP90AA1 5′flanking region were found between the
different breeds. Regression analyses reflected significant
correlations (from 0.41 to 0.62) between the alternative
genotypes of this polymorphism and several climatic and
geographic variables characteristic of the regions where
these breeds are reared. Real-time analysis revealed that
animals bearing the CC−660 genotype presented higher
expression levels than those presenting the CG−660 or
GG−660 in summer, but not in spring. Mutation at −660
site seems to affect HSP90AA1 transcription rates which
could have important effects on the adaptation to different
environmental conditions in sheep. Thus, the variability
found in the genotype frequencies for the SNP at −660 in
the ovine HSP90AA1 locus could be the result of the
different environmental pressures occurring in the regions
where these breed are maintained.
Description
Keywords
Heat schock genes, Polymorphisms, Expression, Thermal adaptation, Ovine species
Bibliographic citation
Marcos-Carcavilla, Ane; Mutikainen, Mari; Gonzalez, Carmen; Calvo, Jorge H.; Kantanen, Juha; Sanz, Albina; Marzanov, Nurbiy S.; Pérez-Guzmán, M. Dolores; Serrano, Magdalena. "A SNP in the HSP90AA1 gene 5′ flanking region is associated with the adaptation to differential thermal conditions in the ovine species". Cell stress and chaperones. 2010, vol. 15, p. 67-81
Other field subjects
OvinosGenotipos
Factores climáticos
ADN
Producción y sanidad animal