Antioxidant, Antidiabetic, and Anti-Obesity Properties of Apple Pulp Extracts (Malus domestica Bork): A Comparative Study of 15 Local and Commercial Cultivars from Spain

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dc.contributor.authorMillán-Laleona, Adrián
dc.contributor.authorBielsa Gonzalez, Francisco Javier
dc.contributor.authorAranda-Cañada, Eduardo
dc.contributor.authorGomez-Rincon, Carlota
dc.contributor.authorErrea Abad, María Pilar
dc.contributor.authorLópez, Victor
dc.contributor.orcidBielsa González, Francisco Javier [0000-0001-5852-6804]
dc.contributor.orcidErrea Abad, María Pilar [0000-0002-2889-1728]
dc.date.accessioned2026-02-25T09:09:29Z
dc.date.available2026-02-25T09:09:29Z
dc.date.issued2023-06-21
dc.date.updated2026-02-25T08:58:53Z
dc.description.abstractApples (Malus domestica Borkh.) have a great agricultural and economic impact worldwide; they also present an interesting nutritional value, and their consumption has been associated with beneficial health effects. In this study, 15 apple varieties (three commercial, 12 autochthonous genotypes) were collected from mountainous areas in Spain and were evaluated for their phenolic content, antioxidant, anti-obesity and antidiabetic activities. Quercetin was tested as the reference substance in bioassays due to its role as one of the most common flavonoids in apples and other vegetables. Total Phenolic Content (TPC) of apple pulp extracts was quantified using the Folin-Ciocalteu method. The antioxidant activity was determined by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging and xanthine/xanthine oxidase (X/XO) scavenging assays. Antidiabetic and anti-obesity potential were evaluated by inhibition of alpha-glucosidase (α-GLU), advance glycation end products (AGEs) formation and pancreatic lipase. The results showed in general higher phenol content in autochthonous varieties than in commercial apple pulp extracts. Phenolic-rich extracts showed better antioxidant profiles and significantly inhibited AGEs production and the α-glucosidase enzyme in a dose-dependent manner. None of them showed pancreatic lipase inhibitory effects but in general, the genotype known as “Amarilla de Octubre” was the best in terms of TPC and bioactive properties.
dc.description.peerreviewedSi
dc.description.sponsorshipAPPLECUT project (ref. PID2019-108081RR-C21), financed by the 2019 call of the Ministry of Science and Innovation oriented to challenges of society. To the Government of Aragon for the financing of the Phyto-Pharm group (ref. B44_20D).
dc.identifier.citationMillán-Laleona, A., Bielsa, F. J., Aranda-Cañada, E., Gómez-Rincón, C., Errea, P., & López, V. (2023). Antioxidant, Antidiabetic, and Anti-Obesity Properties of Apple Pulp Extracts (Malus domestica Bork): A Comparative Study of 15 Local and Commercial Cultivars from Spain. Biology, 12(7). https://doi.org/10.3390/biology12070891
dc.identifier.doi10.3390/biology12070891
dc.identifier.issn2079-7737
dc.identifier.urihttps://doi.org/10.3390/biology12070891
dc.identifier.urihttps://hdl.handle.net/10532/8148
dc.language.isoen
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2019-108081RR-C21/ES/VALORIZACION DE LA DIVERSIDAD GENETICA DEL MANZANO AUTOCTONO PARA UN MAYOR VALOR AÑADIDO EN FRESCO Y TRANSFORMACION: COMPUESTOS BIOACTIVOS Y MECANISMOS MOLECULARES/APPLECUT
dc.relation.citaSi
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.agrovocMalus domestica
dc.subject.agrovocCompuesto fenólico
dc.subject.agrovocAntioxidante
dc.subject.agrovocAlfa glucosidasa
dc.subject.agrovocVariedad indígena
dc.subject.agrovocVariedad
dc.subject.sdgHambre cero
dc.titleAntioxidant, Antidiabetic, and Anti-Obesity Properties of Apple Pulp Extracts (Malus domestica Bork): A Comparative Study of 15 Local and Commercial Cultivars from Spain
dc.typeartículo original
dc.type.hasVersionversión publicada

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