Rev1 wbdR tagged vaccines against Brucella ovis
Loading...
Date
2019
Authors
Aragón Aranda, BeatrizMiguel López, María Jesús de
Martínez Gómez, Estrella
Zúñiga Ripa, Amaia
Salvador Bescós, Miriam
Moriyón Uria, Ignacio
Iriarte, Maite
Muñoz Álvaro, Pilar María
Conde Álvarez, Raquel
Journal Title
Journal ISSN
Volume Title
Publisher
Typology
Journal ContributionArticle
Abstract
Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.
Description
Keywords
Bibliographic citation
Veterinary Research, vol. 50, (2019)
AGROVOC subjects
BrucellaBrucelosis
Vacuna