Rev1 wbdR tagged vaccines against Brucella ovis

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dc.bibliographicCitation.titleVeterinary Researchen
dc.bibliographicCitation.volume50es_ES
dc.contributor.authorAragón Aranda, Beatrizes_ES
dc.contributor.authorMiguel López, María Jesús dees_ES
dc.contributor.authorMartínez Gómez, Estrellaes_ES
dc.contributor.authorZúñiga Ripa, Amaiaes_ES
dc.contributor.authorSalvador Bescós, Miriames_ES
dc.contributor.authorMoriyón Uria, Ignacioes_ES
dc.contributor.authorIriarte, Maitees_ES
dc.contributor.authorMuñoz Álvaro, Pilar Maríaes_ES
dc.contributor.authorConde Álvarez, Raqueles_ES
dc.coverage.spatialProducción y sanidad animales_ES
dc.date.accessioned2019-12-02T12:36:41Z
dc.date.available2019-12-02T12:36:41Z
dc.date.issued2019es_ES
dc.description.abstractSheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.en
dc.description.statusPublishedes_ES
dc.identifier.citationVeterinary Research, vol. 50, (2019)
dc.identifier.urihttp://hdl.handle.net/10532/4895
dc.language.isoenes_ES
dc.relation.doi10.1186/s13567-019-0714-3es_ES
dc.relation.urihttps://doi.org/10.1186/s13567-019-0714-3es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subject.agrovocBrucellaes
dc.subject.agrovocBrucelosises
dc.subject.agrovocVacunaes
dc.titleRev1 wbdR tagged vaccines against Brucella ovisen
dc.typeJournal Contribution*
dc.type.refereedRefereedes_ES
dc.type.specifiedArticlees_ES

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