A Review on the Methodology and Use of the Pregnant Mouse Model in the Study of Brucella Reproductive Pathogenesis and Its Abortifacient Effect

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dc.bibliographicCitation.issue5es_ES
dc.bibliographicCitation.stpage866es_ES
dc.bibliographicCitation.titleMicroorganismsen
dc.bibliographicCitation.volume12es_ES
dc.contributor.authorElizalde Bielsa, Aitores_ES
dc.contributor.authorMuñoz Álvaro, Pilar Maríaes_ES
dc.contributor.authorZúñiga Ripa, Amaiaes_ES
dc.contributor.authorConde Álvarez, Raqueles_ES
dc.date.accessioned2024-05-03T11:16:55Z
dc.date.available2024-05-03T11:16:55Z
dc.date.issued2024es_ES
dc.date.updated2024-05-03T11:10:48Z
dc.description.abstractBrucellosis is one of the most common and widespread bacterial zoonoses and is caused by Gram-negative bacteria belonging to the genus Brucella. These organisms are able to infect and replicate within the placenta, resulting in abortion, one of the main clinical signs of brucellosis. Although the mouse model is widely used to study Brucella virulence and, more recently, to evaluate the protection of new vaccines, there is no clear consensus on the experimental conditions (e.g., mouse strains, doses, routes of inoculation, infection/pregnancy time) and the natural host reproducibility of the pregnant mouse model for reproductive brucellosis. This lack of consensus calls for a review that integrates the major findings regarding the effect of Brucella wild-type and vaccine strains infections on mouse pregnancy. We found sufficient evidence on the utility of the pregnant mouse model to study Brucella-induced placentitis and abortion and propose suitable experimental conditions (dose, time of infection) and pregnancy outcome readouts for B. abortus and B. melitensis studies. Finally, we discuss the utility and limitations of the pregnant mouse as a predictive model for the abortifacient effect of live Brucella vaccines.en
dc.description.otherBrucellaen
dc.description.otherpregnant mouseen
dc.description.othervaccineen
dc.description.otherabortionen
dc.description.otherreproductive pathogenesisen
dc.description.othertrophoblasten
dc.description.otherplacentaen
dc.description.othermodelen
dc.description.sponsorshipEsta revisión se ha realizado en el marco de los proyectos PID2019-107601RB-C31 y PID2019-107601RA-C32 financiados por MCIN/AEI/10.1303910.13039/501100011033. El trabajo de A.E-B fue apoyado por una Beca de Doctorado financiada por el Instituto de Salud Tropical Universidad de Navarra (ISTUN) financiadores (Fundación la CAIXA [LCF/PR/PR13/51080005], Fundación María Francisca de Roviralta, y Ubesol) y el proyecto REPRODIVAC bajo el Acuerdo de Subvención No. 10106081 a través de la Convocatoria HORIZON-CL6-2021-FARM2FORK-01-06. El trabajo de P.M.M (CITA) también fue apoyado por el Gobierno de Aragón (Grupo de Investigación A21_23R).es_ES
dc.description.statusPublishedes_ES
dc.identifier.citationElizalde-Bielsa, A., Muñoz, P. M., Zúñiga-Ripa, A., & Conde-Álvarez, R. (2024). A Review on the Methodology and Use of the Pregnant Mouse Model in the Study of Brucella Reproductive Pathogenesis and Its Abortifacient Effect. Microorganisms, 12(5), Article 5. https://doi.org/10.3390/microorganisms12050866
dc.identifier.issn20762607
dc.identifier.urihttp://hdl.handle.net/10532/6992
dc.language.isoenes_ES
dc.relation.doihttps://doi.org/10.3390/microorganisms12050866es_ES
dc.relation.urihttps://doi.org/10.3390/microorganisms12050866es_ES
dc.rightsCreative Commons Attribution (CC BY) licensees_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.agrovocBrucellaen
dc.subject.agrovocRatónen
dc.subject.agrovocAnimales de laboratorioen
dc.subject.agrovocPlacentaen
dc.subject.agrovocEmbriones animalesen
dc.subject.agrovocPatogénesisen
dc.subject.agrovocAbortoen
dc.subject.agrovocVacunaen
dc.subject.otherAborto
dc.subject.otherAnimales de laboratorio
dc.subject.otherBrucella
dc.subject.otherEmbriones Animales
dc.subject.otherPatogénesis
dc.subject.otherPlacenta
dc.subject.otherRatón
dc.subject.otherVacuna
dc.titleA Review on the Methodology and Use of the Pregnant Mouse Model in the Study of Brucella Reproductive Pathogenesis and Its Abortifacient Effecten
dc.typearticle*
dc.type.refereedRefereedes_ES
dc.type.specifiedArticlees_ES

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