Valorization of local regional apple (Malus domestica Borkh.) cultivars versus commercial samples from Spain: Phenolic compounds by HPLC-MS/MS, cytotoxicity and biological potential on nitric oxide radicals and lipoxygenase inhibition

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dc.bibliographicCitation.stpage106631es_ES
dc.bibliographicCitation.titleJournal of Functional Foodsen
dc.bibliographicCitation.volume124es_ES
dc.contributor.authorMillán-Laleona, Adriánes_ES
dc.contributor.authorCebollada, Pilares_ES
dc.contributor.authorCaprioli, Giovannies_ES
dc.contributor.authorPiatti, Dilettaes_ES
dc.contributor.authorMaggi, Filippoes_ES
dc.contributor.authorPina Sobrino, Anaes_ES
dc.contributor.authorGomez-Rincon, Carlotaes_ES
dc.contributor.authorLópez, Victores_ES
dc.coverage.spatialCiencia vegetales_ES
dc.date.accessioned2025-01-10T11:45:07Z
dc.date.available2025-01-10T11:45:07Z
dc.date.issued2024es_ES
dc.date.updated2024-12-19T07:00:09Z
dc.description.abstractSustainability in the fruit industry and protection of local cultivars are nowadays important tasks for consumers and authorities. Phenolic compounds are interesting to explore because they play an important role in fruit-related health benefits. The phenolic profile of the regional and commercial Spanish apple cultivars was performed by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). For a deeper understanding of their anti-inflammatory and antioxidant potential, the 5-lipoxigenase inhibition and NO? scavenging were evaluated. Moreover, cellular viability was determined to perform MTT assay in HepG2 and HeLa cell lines to discard cytotoxicity. The results showed that procyanidin B2 (PB2), 3-caffeoylquinic acid, epicatechin and 4-hydroxy benzoic acid were the most abundant phenolic compounds. Autochthonous apple cultivars showed better 5-LOX/NO? inhibition and nontoxic effects in the tested cell lines with an interesting profile of phenolic compounds. Local autochthonous apples can be considered a better source of bioactive compounds than the commercial samples.en
dc.description.otherFruitsen
dc.description.otherAppleen
dc.description.otherPolyphenolsen
dc.description.otherFlavonoidsen
dc.description.otherHPLC-MS/MSen
dc.description.otherAnti-inflammatoryen
dc.description.sponsorshipAPPLECUT (ref. PID2019-108081RR-C21) and APPLEDIV (PID2022- 141847OR-C31, PID2022-141847OR-C33) projects, financed by the 2019 and 2022 calls of the Ministry of Science and Innovation oriented to challenges of society.es_ES
dc.description.statusPublishedes_ES
dc.identifier.citationMillán-Laleona, A., Cebollada, P., Caprioli, G., Piatti, D., Maggi, F., Pina, A., Gómez-Rincón, C., & López, V. Valorization of local regional apple (Malus domestica Borkh.) cultivars versus commercial samples from Spain: Phenolic compounds by HPLC-MS/MS, cytotoxicity and biological potential on nitric oxide radicals and lipoxygenase inhibition. Journal of Functional Foods, 2024, 124, 106631
dc.identifier.issn17564646
dc.identifier.urihttp://hdl.handle.net/10532/7434
dc.language.isoenes_ES
dc.relation.doihttps://doi.org/10.1016/j.jff.2024.106631es_ES
dc.relation.urihttps://doi.org/10.1016/j.jff.2024.106631es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Españaes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/es_ES
dc.subject.agrovocMaluses
dc.subject.agrovocManzanaes
dc.subject.agrovocPolifenoleses
dc.subject.agrovocFlavonoideses
dc.subject.agrovocAntinflamatorioses
dc.subject.agrovocLipoxigenasaes
dc.subject.otherAntinflamatorios
dc.subject.otherCromatografía de líquidos (uv, luminiscente, ms, electroquímica, etc)
dc.subject.otherFlavonoides
dc.subject.otherlipoxigenasa
dc.subject.otherMALUS
dc.subject.otherManzana
dc.subject.otherPolifenoles
dc.titleValorization of local regional apple (Malus domestica Borkh.) cultivars versus commercial samples from Spain: Phenolic compounds by HPLC-MS/MS, cytotoxicity and biological potential on nitric oxide radicals and lipoxygenase inhibitionen
dc.typeJournal Contribution*
dc.type.refereedRefereedes_ES
dc.type.specifiedArticlees_ES

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